Stabilizing HIF to Ameliorate Anemia
نویسندگان
چکیده
منابع مشابه
HIF stabilizing agents: shotgun or scalpel?
THE FETUS DEVELOPS IN HYPOXIA (3–5% O2), which is essential for the vasculature. Vascular growth, in turn, is required for lung development (11). For these processes, the essential role of the transcription factor hypoxia-inducible factor (HIF) is increasingly apparent. Genetic inactivation of either HIF-1 or -2 in mice leads to fetal or neonatal lethality because of major developmental defects...
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Tissue hypoxia likely contributes to anemia-induced organ injury and mortality. Severe anemia activates hypoxia-inducible factor (HIF) signaling by hypoxic- and neuronal nitric oxide (NO) synthase- (nNOS) dependent mechanisms. However, organ-specific hemoglobin (Hb) thresholds for increased HIF expression have not been defined. To assess organ-specific Hb thresholds for tissue hypoxia, HIF-α (o...
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ژورنال
عنوان ژورنال: Cell
سال: 2020
ISSN: 0092-8674
DOI: 10.1016/j.cell.2019.12.010